Molecular and Cellular Basis of Inflammatory and Immunodeficiency Diseases

Antigen-driven EGR2 expression is required for exhausted CD8 T cell stability and maintenance

MV Wagle, SJ Vervoort, MJ Kelly, W Van Der Byl, TJ Peters, BP Martin, LG Martelotto, S Nüssing, KM Ramsbottom, JR Torpy, D Knight, S Reading, K Thia, LA Miosge, DR Howard, R Gloury, SS Gabriel, DT Utzschneider, J Oliaro, JD Powell

2021-12-01

Chronic stimulation of CD8⁺ T cells triggers exhaustion, a distinct differentiation state with diminished effector func..

Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells

RC Wirasinha, A Chan, JY Yap, DY Hu, CE Teh, DHD Gray, CC Goodnow, SR Daley

2019-12-01

The selection of αβ T cells in the thymus is punctuated by checkpoints at which thymocytes differentiate or undergo apoptosis. Wav..

Germline-activating mutations in PIK3CD compromise B cell development and function

DT Avery, A Kane, T Nguyen, A Lau, A Nguyen, H Lenthall, K Payne, W Shi, H Brigden, E French, J Bier, JR Hermes, D Zahra, WA Sewell, D Butt, M Elliott, K Boztug, I Meyts, S Choo, P Hsu

2018-09-01

Gain-of-function (GOF) mutations in PIK3CD, encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary i..

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8 T Cell Tolerance Checkpoint to High-Dose Antigen

MV Wagle, JM Marchingo, J Howitt, SS Tan, CC Goodnow, IA Parish

2018-07-17

Escape from peripheral tolerance checkpoints that control cytotoxic CD8⁺ T cells is important for cancer immunotherapy ..

Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation

DL Burnett, IA Parish, E Masle-Farquhar, R Brink, CC Goodnow

2017-10-01

Inherited mutations in lipopolysaccharide-responsive beige-like anchor (LRBA) cause a recessive human immune dysregulation syndrom..

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

LA Miosge, Y Sontani, A Chuah, K Horikawa, TA Russell, Y Meia, MV Wagle, DR Howard, A Enders, DC Tscharke, CC Goodnow, IA Parish

2017-06-27

T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphocytes to form effector cells. Here..

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

E Mariño, JL Richards, KH McLeod, D Stanley, YA Yap, J Knight, C McKenzie, J Kranich, AC Oliveira, FJ Rossello, B Krishnamurthy, CM Nefzger, L Macia, A Thorburn, AG Baxter, G Morahan, LH Wong, JM Polo, RJ Moore, TJ Lockett

2017-04-18

Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese diabetic (NOD) strain, we found that ke..

FOXO3 is differentially required for CD8 T-cell death during tolerance versus immunity

MV Wagle, IA Parish

2016-10-01

Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8⁺ T cells from the pe..

A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy

IA Parish, LA Stamp, AMD Lorenzo, SM Fowler, Y Sontani, LA Miosge, DR Howard, CC Goodnow, HM Young, JB Furness

2016-09-01

Chronic intestinal pseudo-obstruction (CIPO) is a rare but life-threatening disease characterized by severe intestinal dysmotility..

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion

Z Wu, R Liang, T Ohnesorg, V Cho, W Lam, WP Abhayaratna, PA Gatenby, C Perera, Y Zhang, B Whittle, A Sinclair, CC Goodnow, M Field, TD Andrews, MC Cook

2016-05-01

Most humans harbor both CD177^neg and CD177^pos neutrophils but 1–10% of people are CD177^null, plac..

Differential responsiveness of innate-like IL-17- and IFN-γ- producing γδ T cells to homeostatic cytokines

TM Corpuz, J Stolp, HO Kim, GV Pinget, DHD Gray, JH Cho, J Sprent, KE Webster

2016-01-15

γδ T cells respond to molecules upregulated following infection or cellular stress using both TCR and non-TCR molecules. The impor..

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

RR Ramiscal, IA Parish, RS Lee-Young, JJ Babon, J Blagih, A Pratama, J Martin, N Hawley, JY Cappello, PF Nieto, JI Ellyard, NJ Kershaw, RA Sweet, CC Goodnow, RG Jones, MA Febbraio, CG Vinuesa, V Athanasopoulos

2015-10-23

T follicular helper cells (Tfh) are critical for the longevity and quality of antibody- mediated protection against infection. Yet..

BAFF-driven autoimmunity requires CD19 expression

KA Fairfax, E Tsantikos, WA Figgett, FB Vincent, PS Quah, M LePage, ML Hibbs, F Mackay

2015-08-01

B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for B cell survival and maturatio..

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

RP Wilson, ML Ives, G Rao, A Lau, K Payne, M Kobayashi, PD Arkwright, J Peake, M Wong, S Adelstein, JM Smart, MA French, DA Fulcher, C Picard, J Bustamante, S Boisson-Dupuis, P Gray, P Stepensky, K Warnatz, AF Freeman

2015-06-01

Unconventional T cells such as γδ T cells, natural killer T cells (NKT cells) and mucosal-associated invariant T cells (MAIT cells..

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production

D Butt, TD Chan, K Bourne, JR Hermes, A Nguyen, A Statham, LA O'Reilly, A Strasser, S Price, P Schofield, D Christ, A Basten, CS Ma, SG Tangye, TG Phan, VK Rao, R Brink

2015-05-19

The mechanistic links between genetic variation andautoantibody production in autoimmune disease remain obscure. Autoimmune lympho..

IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival

KE Webster, HO Kim, K Kyparissoudis, TM Corpuz, GV Pinget, AP Uldrich, R Brink, GT Belz, JH Cho, DI Godfrey, J Sprent

2014-01-01

Natural killer T (NKT) cells are innate-like T cells that rapidly recognize pathogens and produce cytokines that shape the ensuing..